Dr. Silvia De Paoli

Dr. Silvia De Paoli

Chemist

FDA

United States

• Doctor of Philosophy, Major: Chemistry Diploma with Honors – University of Sao Paulo, Sao Paulo, Brazil (2001)

• FDA Regulatory Experiences:
June 2019‐present: FDA/CBER, Pharmacology/Toxicology Reviewer for PMA, BLA, IDE, 510(k), etc)

2009‐2019: FDA/CBER, Chemistry, Manufacturing, and Controls (CMC) reviewer of medical devices and biologics

• Research positions (over 40 articles in peer reviewed journals)

2009‐2019: FDA/CBER – Research Chemist
o Research on characterization of platelet‐derived microparticles
o Characterization of protein therapeutic formulations
o Effect of nanoparticles on the stability of plasma proteins
o Nanomaterial physical chemical characterization and interactions with blood products

2006‐ 2009: National Institute of Standards and Technology (NIST) – Guest Researcher
o Biocompatibility of nanoparticles, drugs and their complexes with plasma proteins

2007- Kyoto Institute of Technology (Japan) – Visiting Scientist
o Development of methodology for cell and tissue imaging using 3‐D transmission electron microscopy

2004‐2005 – Advanced Material Research Institute, New Orleans, LA – Postdoctoral Research Associate
o Protein‐based hydrogels
o Nanodevices for controlled drug release

2005- Hebrew University of Jerusalem – Invited Research Scientist
o Design of protein‐nanoparticle complexes as sensors for quantitative analysis of iron contents in biological systems

2002‐ 2004 – University of Wisconsin, School of Pharmacy, Madison, WI – Postdoctoral Research Associate
o Drug design and testing for photodynamic therapy of cancer

2001‐2002 – Marquette University, Chemistry Department, Milwaukee, WI, – Postdoctoral Research Associate
o Determination of protein identity and sequence of peptides by Raman imaging technique and NIR spectroscopy

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