Sanghamitra Mishra
Co-founder and Managing Director
Sanghamitra Mishra, a European Registered Toxicologist (ERT) and Diplomate of the American Board of Toxicology (DABT), is co-founder and Managing Director of NexGenTox Pvt. Ltd., a Bengaluru-based toxicology consultancy. She has over 18 years’ experience in hazard characterisation, human and environmental risk assessment and regulatory toxicology across chemicals, cosmetics, biocides and pharmaceuticals.
Her work applies new approach methodologies, including QSAR, read-across, in vitro methods and AOP-informed strategies, to reduce animal testing. This extends to her doctoral research at Liverpool John Moores University on PBK modelling and QIVIVE.
Prior to NexGenTox, she established the India operations of ToxMinds BV and currently serves as its technical adviser. She has prepared dossiers under REACH, BPR and the EU Cosmetics Regulation, derived exposure limits under ICH guidelines, and engaged directly with EMA, ECHA, SCCS and the CIR Expert Panel.
DAY 2: December 2nd, 2026
SESSION: Building a defensible read-across justification for NDSRI acceptable intakes
◆ Deriving substance-specific acceptable intakes beyond CPCA-based values: practical examples of when read-across supports an alternative intake and when it does not.
◆ Establishing a robust read-across justification beyond structural similarity: the importance of scientific evidence and expert judgement in supporting surrogate selection.
◆ Building a weight-of-evidence justification for the surrogate-based acceptable intake using additional evidence, including comparative potency, steric hindrance and bioavailability potential.
◆ Preparing a clear justification for regulatory submission: explaining the proposed acceptable intake and addressing uncertainties.
