Jan Wenzel
Senior Principal Scientist – Applied Digital Toxicology Expert
Jan Wenzel studied chemistry at the Goethe University Frankfurt, focusing research projects in computational quantum chemistry. His PhD was received from the University of Heidelberg, where he conducted fundamental research for simulation of X-ray absorption spectroscopy. Afterwards, Jan started as PostDoc at Sanofi in Frankfurt. The project’s focus was on artificial intelligence methods and deep learning in the field of safety analytics, to advance the capabilities to analyze, predict and optimize safety parameters of novel drug candidates. Currently, Jan is a Senior Principal Scientist in the Toxicology Innovations group at Sanofi. Besides QSAR and artificial intelligence topics in the field of preclinical safety, Jan also supports the analysis of the genotoxic potential of N-Nitrosamine impurities with computational quantum chemical methods.
DAY 2: December 3rd, 2026
SESSION: In silico risk assessment of NAs using quantum chemistry to estimate ethe reactivity and mutagenicity of NAs
◆ Computational toxicology/chemistry support of Nitrosamines de-risking.
◆ In silico risk assessment of Nitrosamines using quantum chemistry to estimate the reactivity and mutagenicity of Nitrosamines.
◆ Demonstrating recent examples.
DAY 1: December 2nd, 2021
SESSION: A Quantum Chemical Approach to Estimate the Mutagenic Potential of Nitrosamines After Metabolic Activation
◆ Computational quantum chemistry approach to assess the reactivity of Nitrosamines.
◆ Introduction of metabolic activation in the calculation of reactivity.
◆ Case studies on different nitrosamines.
